关于举行芝加哥大学张睿博士学术报告的通知

报告题目：C–C activation of unstrained substrates:from ketones to amides报 告 人：芝加哥大学张睿博士邀 请 人：吴钊教授时   间：2024年3月4日（星期一）上午10:30地   点：广州国际校区C3-c204（腾讯会议：243-642-574）欢迎广大师生踊跃参加。  前沿软物质学院华南软物质科学与技术高等研究院2024年2月29日 报告摘要：C–C activation reactions have attracted significant interest in the past decades due to their efficiency in constructing or editing complex molecular backbones.Current C–C activation transformations mainly include strained rings, pre-aromatized intermediates,forming strong M–CN bonds or β-scission to give stable products. These requirements in substrate patterns largely limit their further applications.Therefore,novel strategies to selective activate C–C bonds in more general substrates are still highly sought after. In this seminar, I will introduce my work on the strategic manipulation of C–C bonds in unstrained ketones and amides.With rationally designed activation reagents and ligands,we achieved the efficient structural editing for general ketones and amides,including annulation,homologation,and ring contraction.These transformations offer new strategies for chemical synthesis and broaden the space for derivatization of bioactive molecules. 报告人简介：张睿博士，2019年本科毕业于北京大学，师从王剑波教授。2019—2024年在芝加哥大学董广彬教授课题组攻读博士学位，主要研究方向是过渡金属催化的非张力底物碳碳键活化。迄今已在Science,Nat.Chem.,Angew.Chem.Int.Ed.等国际期刊以第一作者或共同第一作者身份发表研究成果。曾获得芝加哥大学Alfred R.Bader学生研究奖（2021）和百时美施贵宝奖学金（2022）。